Achetez et telechargez ebook applied surrogate endpoint evaluation methods with sas and r chapman hall crc biostatistics series english edition boutique kindle probability statistics amazonfr. When a true endpoint is difficult to use because of such factors as long follow up times or prohibitive cost it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost effective way this book focuses on the use of surrogate endpoint evaluation methods in practice using sas and r. Applied surrogate endpoint evaluation methods with sas and r ariel alonso theophile bigirumurame tomasz burzykowski marc buyse geert molenberghs leacky muchene nolen joy perualila ziv shkedy wim van der elst chapman hall crc biostatics series 2017 xxi 373 5799 gbp isbn 13 978 1 4822 4936 1 hardback. Applied surrogate endpoint evaluation methods with sas and r ariel alonso theophile bigirumurame tomasz burzykowski marc buyse geert molenberghs leacky muchene nolen joy perualila ziv . An important factor that affects the duration complexity and cost of a clinical trial is the endpoint used to study the treatments efficacy when a true endpoint is difficult to use because of such factors as long follow up times or prohibitive cost it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost effective way this book focuses on